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Epetraborole (hydrochloride)

CAT: 0804-HY-12479A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12479A-01Size:1 mg
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Description
Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3].
CAS Number
1234563-16-6
Product Name Alternative
GSK2251052 hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aminoacyl-tRNA Synthetase; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Epetraborole-hydrochloride.html
Purity
99.62
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : ≥ 28 mg/mL
Smiles
OCCCOC1=C(B(O)O[C@@H]2CN)C2=CC=C1.[H]Cl
Molecular Formula
C11H17BClNO4
Molecular Weight
273.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57 (5) :2401-4.|[2]O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59 (1) :289-98.|[3]Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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