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SLC19A1 Antibody

CAT: 0223-29-961Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-29-961Size:100 µL
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Background
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. SLC19A1 plays a role in maintaining intracellular concentrations of folate.Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
NCBI Gene ID
6573
Swiss Prot
P41440
Accession Number
NP_919231
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SLC19A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SLC19A1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
65 kDa
Applications Notes
SLC19A1 antibody can be used for detection of SLC19A1 by ELISA at 1:1562500. SLC19A1 antibody can be used for detection of SLC19A1 by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SLC19A1
NCBI Official Name
Solute carrier family 19 (folate transporter), member 1
NCBI Organism
Homo sapiens
Background Reference 01
Payton, S.G., (2005) Biochim. Biophys. Acta 1731 (2), 115-124.
Other Product Names
SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1
Tested Applications
ELISA, WB, IHC
Protein ID
34808710
Physical Properties
Liquid

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