M6PR Antibody

• Background:

  M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.The protein encoded by this gene is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.

• NCBI Gene ID:

  4074

• Swiss Prot:

  P20645

• Accession Number:

  NP_002346

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human M6PR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane, Signal Transduction

• Purification:

  Antibody is purified by protein A chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store M6PR antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  28 kDa

• Applications Notes:

  M6PR antibody can be used for detection of M6PR by ELISA at 1:312500. M6PR antibody can be used for detection of M6PR by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  M6PR

• NCBI Official Name:

  Mannose-6-phosphate receptor (cation dependent)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, J.J., (2004) Cell 119 (7), 915-926.

• Other Product Names:

  M6PR, CD-MPR, FLJ32994, MPR46, SMPR, MPR 46, MPR-46

• Tested Applications:

  ELISA, WB

• Protein ID:

  4505061

• Physical Properties:

  Liquid