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GFI1 Antibody

CAT: 0223-27-632Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-632Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
NCBI Gene ID
2672
Swiss Prot
Q99684
Accession Number
NP_005254
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GFI1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cell Cycle, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10410 - Fetal Lung Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store GFI1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
45 kDa
Applications Notes
GFI1 antibody can be used for detection of GFI1 by ELISA at 1:312500. GFI1 antibody can be used for detection of GFI1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
GFI1
NCBI Official Name
Growth factor independent 1 transcription repressor
NCBI Organism
Homo sapiens
Background Reference 01
Huh, H.J., (er) Int J Lab Hematol (2008) In press.
Other Product Names
GFI1, ZNF163, SCN2, GFI-1, GFI1A
Tested Applications
ELISA, WB
Protein ID
71037377
Physical Properties
Liquid

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