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SNF8 Antibody

CAT: 0223-27-366Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-366Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML) . In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]) .
NCBI Gene ID
11267
Swiss Prot
Q96H20
Accession Number
NP_009172
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SNF8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SNF8 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
29 kDa
Applications Notes
SNF8 antibody can be used for detection of SNF8 by ELISA at 1:1562500. SNF8 antibody can be used for detection of SNF8 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SNF8
NCBI Official Name
SNF8, ESCRT-II complex subunit
NCBI Organism
Homo sapiens
Background Reference 01
Malerod, L., (2007) Traffic 8 (11), 1617-1629.
Other Product Names
SNF8, Dot3, EAP30, VPS22
Tested Applications
ELISA, WB
Protein ID
21361380
Physical Properties
Liquid

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