RGS4 Antibody

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.

5999

P49798

NP_005604

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RGS4.

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

Cat. No. 1205 - Jurkat Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store RGS4 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

23 kDa, 34 kDa

RGS4 antibody can be used for detection of RGS4 by ELISA at 1:312500. RGS4 antibody can be used for detection of RGS4 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

RGS4

Regulator of G-protein signaling 4

Homo sapiens

Ishii, M., (2005) Biochem. Biophys. Res. Commun. 338 (2), 839-846.

RGS4, MGC2124, MGC60244, RGP4, SCZD9

ELISA, WB

5032039