RGS5 Antibody

• Background:

  This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  8490

• Swiss Prot:

  O15539

• Accession Number:

  O15539

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RGS5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human RGS5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  21 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RGS5

• NCBI Official Name:

  Regulator of G-protein signaling 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wang, J., et al. Carcinogenesis 31 (10) :1755-1761 (2010)

• Background Reference 02:

  Li, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (31) :13818-13823 (2010)

• Background Reference 03:

  Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

• Background Reference 04:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Other Product Names:

  Regulator of G-protein signaling 5, RGS5, RGS5

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid