RGS3 Antibody

• Background:

  RGS3 inhibits signal transduction by increasing the GTPASE activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.

• NCBI Gene ID:

  5998

• Swiss Prot:

  P49796

• Accession Number:

  NP_570613

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RGS3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Immunology

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store RGS3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  101 kDa

• Applications Notes:

  RGS3 antibody can be used for detection of RGS3 by ELISA at 1:62500. RGS3 antibody can be used for detection of RGS3 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  RGS3

• NCBI Official Name:

  Regulator of G-protein signaling 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yau, D.M., (2008) Mol. Pharmacol. 73 (5), 1356-1361.

• Other Product Names:

  RGS3, C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ-RGS3, RGP3

• Tested Applications:

  ELISA, WB

• Protein ID:

  62865651

• Physical Properties:

  Liquid