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IKBKG Antibody

CAT: 0223-27-263Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-263Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males . In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito
NCBI Gene ID
8517
Swiss Prot
Q9Y6K9
Accession Number
NP_003630
Host
Rabbit
Reactivity
Human, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human IKBKG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Immunology, Apoptosis
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store IKBKG antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
48 kDa
Applications Notes
IKBKG antibody can be used for detection of IKBKG by ELISA at 1:312500. IKBKG antibody can be used for detection of IKBKG by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
IKBKG
NCBI Official Name
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
NCBI Organism
Homo sapiens
Background Reference 01
Hai, T., et al., (2006) J. Virol. 80 (9), 4227-4241.
Other Product Names
IKBKG, IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, ZC2HC9, IKK-gamma
Tested Applications
ELISA, WB
Protein ID
4504631
Physical Properties
Liquid

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