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PNPO Antibody

CAT: 0223-27-181Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-181Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO; EC 1.4.3.5) .
NCBI Gene ID
55163
Swiss Prot
Q9NVS9
Accession Number
NP_060599
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PNPO.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PNPO antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
29 kDa
Applications Notes
PNPO antibody can be used for detection of PNPO by ELISA at 1:312500. PNPO antibody can be used for detection of PNPO by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PNPO
NCBI Official Name
Pyridoxamine 5'-phosphate oxidase
NCBI Organism
Homo sapiens
Background Reference 01
Song, H., Schizophr. Res. 97 (1-3), 264-270 (2007) .
Other Product Names
PNPO, FLJ10535, PDXPO, HEL-S-302
Tested Applications
ELISA, WB
Protein ID
8922498
Physical Properties
Liquid

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