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KRAS Antibody

CAT: 0223-27-016Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-016Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KRAS is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
NCBI Gene ID
3845
Swiss Prot
P01111
Accession Number
NP_203524
Host
Rabbit
Reactivity
Human, Mouse, Rat, Drosophila
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KRAS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10407 - Fetal Heart Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KRAS antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
22 kDa
Applications Notes
KRAS antibody can be used for detection of KRAS by ELISA at 1:62500. KRAS antibody can be used for detection of KRAS by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
KRAS
NCBI Official Name
Kirsten rat sarcoma viral oncogene homolog
NCBI Organism
Homo sapiens
Background Reference 01
Turbiner, J., (er) Mod. Pathol. (2008) In press.
Other Product Names
KRAS, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS3, RASK2, NS, CFC2
Tested Applications
ELISA, WB
Protein ID
15718763
Physical Properties
Liquid

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