DAAM1 Antibody

CAT: 0223-26-970Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-26-970Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
NCBI Gene ID
23002
Swiss Prot
Q9Y4D1
Accession Number
NP_055807
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DAAM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
293T Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store DAAM1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
123 kDa
Applications Notes
DAAM1 antibody can be used for detection of DAAM1 by ELISA at 1:62500. DAAM1 antibody can be used for detection of DAAM1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
DAAM1
NCBI Official Name
Dishevelled associated activator of morphogenesis 1
NCBI Organism
Homo sapiens
Background Reference 01
Higashi, T., (2008) J. Biol. Chem. 283 (13), 8746-8755.
Other Product Names
DAAM1, FLJ41657, KIAA0666
Tested Applications
ELISA, WB
Protein ID
21071077
Physical Properties
Liquid

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