MLF1 Antibody

• Background :

  MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. It interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

• NCBI Gene ID :

  4291

• Swiss Prot :

  P58340

• Accession Number :

  NP_071888

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MLF1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Antibody is purified by peptide affinity chromatography method.

• Positive Control :

  Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MLF1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  29 kDa

• Applications Notes :

  MLF1 antibody can be used for detection of MLF1 by ELISA at 1:312500. MLF1 antibody can be used for detection of MLF1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  MLF1

• NCBI Official Name :

  Myeloid leukemia factor 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Li, Z.F., J. Neurol. Sci. 264 (1-2), 77-86 (2008) .

• Other Product Names :

  MLF1

• Tested Applications :

  ELISA, WB

• Protein ID :

  11967975

• Physical Properties :

  Liquid