RDH12 Antibody

• Background:

  RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. RDH12 also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3) .The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3) .

• NCBI Gene ID:

  145226

• Swiss Prot:

  Q96NR8

• Accession Number:

  NP_689656

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RDH12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Tranfected 293T Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store RDH12 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  35 kDa

• Applications Notes:

  RDH12 antibody can be used for detection of RDH12 by ELISA at 1:312500. RDH12 antibody can be used for detection of RDH12 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  RDH12

• NCBI Official Name:

  Retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sun, W., (2007) Vision Res. 47 (15), 2055-2066.

• Other Product Names:

  RDH12, FLJ30273, LCA3, RP53, LCA13, SDR7C2

• Tested Applications:

  ELISA, WB

• Protein ID:

  186928839

• Physical Properties:

  Liquid