DCLRE1C Antibody

• Background:

  DCLRE1C is a nuclear protein that is involved in V (D) J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA) . This gene encodes a nuclear protein that is involved in V (D) J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA) .

• NCBI Gene ID:

  64421

• Swiss Prot:

  Q96SD1

• Accession Number:

  NP_001029029

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DCLRE1C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  293T Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store DCLRE1C antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  65 kDa

• Applications Notes:

  DCLRE1C antibody can be used for detection of DCLRE1C by ELISA at 1:2500. DCLRE1C antibody can be used for detection of DCLRE1C by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  DCLRE1C

• NCBI Official Name:

  DNA cross-link repair 1C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bethke, L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276.

• Other Product Names:

  DCLRE1C, A-SCID, DCLREC1C, FLJ11360, FLJ36438, RS-SCID, SCIDA, SNM1C

• Tested Applications:

  ELISA, WB

• Protein ID:

  76496499

• Physical Properties:

  Liquid