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SPOP Antibody

CAT: 0223-26-515Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-26-515Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
NCBI Gene ID
8405
Swiss Prot
O43791
Accession Number
NP_001007227
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SPOP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SPOP antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
42 kDa
Applications Notes
SPOP antibody can be used for detection of SPOP by ELISA at 1:1562500. SPOP antibody can be used for detection of SPOP by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SPOP
NCBI Official Name
Speckle-type POZ protein
NCBI Organism
Homo sapiens
Background Reference 01
Bunce, M.W., (2008) J. Biol. Chem. 283 (13), 8678-8686.
Other Product Names
SPOP, TEF2, BTBD32
Tested Applications
ELISA, WB
Protein ID
56117836
Physical Properties
Liquid

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