SIGIRR Antibody

• Background:

  SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.

• NCBI Gene ID:

  59307

• Swiss Prot:

  Q6IA17

• Accession Number:

  XP_001129013

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SIGIRR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SIGIRR antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  25 kDa

• Applications Notes:

  SIGIRR antibody can be used for detection of SIGIRR by ELISA at 1:62500. SIGIRR antibody can be used for detection of SIGIRR by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  SIGIRR

• NCBI Official Name:

  Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SIGIRR, MGC110992, TIR8

• Tested Applications:

  ELISA, WB

• Protein ID:

  113422713

• Physical Properties:

  Liquid