LRRC8A Antibody

CAT: 0223-26-404Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-26-404Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LRRC8A is a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. LRRC8A is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
NCBI Gene ID
56262
Swiss Prot
Q8IWT6
Accession Number
NP_062540
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LRRC8A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store LRRC8A antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
94 kDa
Applications Notes
LRRC8A antibody can be used for detection of LRRC8A by ELISA at 1:62500. LRRC8A antibody can be used for detection of LRRC8A by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
LRRC8A
NCBI Official Name
Leucine rich repeat containing 8 family, member A
NCBI Organism
Homo sapiens
Background Reference 01
Smits, G. (2004) Mol. Immunol. 41 (5), 561-562.
Other Product Names
LRRC8A, FLJ10337, KIAA1437, LRRC8, AGM5
Tested Applications
ELISA, WB
Protein ID
62241040
Physical Properties
Liquid

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