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LRRC26 Antibody

CAT: 0223-7539-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7539-01Size:0.02 mg
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Background
The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1) . LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2) . LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3) .
NCBI Gene ID
389816
Swiss Prot
Q2I0M4
Accession Number
NP_001013675
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
LRRC26 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1312 - Human Prostate Tissue Lysate
Concentration
1 mg/mL
Buffer
LRRC26 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LRRC26 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
LRRC26 antibody is human specific.
Symbol
LRRC26
Positive Control 2
Cat. No. 1205 - Jurkat Cell Lysate
NCBI Official Name
Leucine rich repeat containing 26
NCBI Organism
Homo sapiens
Background Reference 01
Egland KA, Liu XF, Squires S, et al. High expression of a cytokeratin-associated protein in many cancers. Proc. Natl. Acad. Sci. USA 2006; 103:5929-34.
Background Reference 02
Liu XF, Xiang L, Zhang Y, et al. CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis. Oncogene 2012; 31:1673-82.
Background Reference 03
Almassy J and Begenisich T. The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 2012; 81:21-30.
Other Product Names
LRRC26 Antibody: CAPC, bA350O14.10, CAPC, Leucine-rich repeat-containing protein 26, BK channel auxiliary gamma subunit LRRC26
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
61966761
Physical Properties
Liquid

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