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QPCT Antibody

CAT: 0223-26-343Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-26-343Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
25797
Swiss Prot
Q16769
Accession Number
NP_036545
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human QPCT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store QPCT antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
38 kDa
Applications Notes
QPCT antibody can be used for detection of QPCT by ELISA at 1:62500. QPCT antibody can be used for detection of QPCT by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
QPCT
NCBI Official Name
Glutaminyl-peptide cyclotransferase
NCBI Organism
Homo sapiens
Background Reference 01
Cynis, H., (2008) J. Mol. Biol. 379 (5), 966-980.
Other Product Names
QPCT, GCT, QC, sQC
Tested Applications
ELISA, WB
Protein ID
6912618
Physical Properties
Liquid

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