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TRDMT1 Antibody

CAT: 0223-26-329Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-26-329Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. TRDMT1 is a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome.CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
1787
Swiss Prot
O14717
Accession Number
NP_004403
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TRDMT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TRDMT1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
44 kDa
Applications Notes
TRDMT1 antibody can be used for detection of TRDMT1 by ELISA at 1:312500. TRDMT1 antibody can be used for detection of TRDMT1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
TRDMT1
NCBI Official Name
TRNA aspartic acid methyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Matakidou, A., (2007) Br. J. Cancer 97 (2), 247-252.
Other Product Names
TRDMT1, DNMT2, M.HsaIIP, PuMet, RNMT1, DMNT2, PUMET, MHSAIIP
Tested Applications
ELISA, WB
Protein ID
4758184
Physical Properties
Liquid

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