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PAICS Antibody

CAT: 0223-26-098Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-26-098Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAICS is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
10606
Swiss Prot
P22234
Accession Number
NP_001072992
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PAICS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10123 - Fetal Brain Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PAICS antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
47 kDa
Applications Notes
PAICS antibody can be used for detection of PAICS by ELISA at 1:312500. PAICS antibody can be used for detection of PAICS by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PAICS
NCBI Official Name
Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
NCBI Organism
Homo sapiens
Background Reference 01
Beausoleil, S.A., (2006) Nat. Biotechnol. 24 (10), 1285-1292.
Other Product Names
PAICS, ADE2, ADE2H1, AIRC, DKFZp781N1372, MGC1343, MGC5024, PAIS
Tested Applications
ELISA, WB
Protein ID
119220557
Physical Properties
Liquid

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