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GGCX Antibody

CAT: 0223-25-950Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-25-950Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency.Gamma-glutamyl carboxylase accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins (Wu et al., 1991 [PubMed 1749935]) . These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP; MIM 112260) and bone matrix protein (MGP; MIM 154870) .
NCBI Gene ID
2677
Swiss Prot
P38435
Accession Number
NP_000812
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GGCX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1219 - MCF7 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store GGCX antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
87 kDa
Applications Notes
GGCX antibody can be used for detection of GGCX by ELISA at 1:1562500. GGCX antibody can be used for detection of GGCX by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
GGCX
NCBI Official Name
Gamma-glutamyl carboxylase
NCBI Organism
Homo sapiens
Background Reference 01
Rieder, M.J., (2007) J. Thromb. Haemost. 5 (11), 2227-2234.
Other Product Names
GGCX, FLJ26629, VKCFD1
Tested Applications
ELISA, WB
Protein ID
21361163
Physical Properties
Liquid

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