GCHFR Antibody

• Background:

  GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

• NCBI Gene ID:

  2644

• Swiss Prot:

  P30047

• Accession Number:

  NP_005249

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GCHFR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store GCHFR antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  10 kDa

• Applications Notes:

  GCHFR antibody can be used for detection of GCHFR by ELISA at 1:312500. GCHFR antibody can be used for detection of GCHFR by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  GCHFR

• NCBI Official Name:

  GTP cyclohydrolase I feedback regulator

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ohta, E., (2006) Arch. Neurol. 63 (11), 1605-1610.

• Other Product Names:

  GCHFR, GFRP, HsT16933, MGC138467, MGC138469, P35

• Tested Applications:

  ELISA, WB

• Protein ID:

  4885257

• Physical Properties:

  Liquid