AGTR1 Antibody

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.

185

P30556

NP_004826

Human, Mouse, Rat, Dog

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AGTR1.

Unconjugated

Primary Antibodies

Membrane, Cancer, Signal Transduction, Immunology

Antibody is purified by peptide affinity chromatography method.

Cat. No. XBL-10407 - Fetal Heart Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store AGTR1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

41 kDa

AGTR1 antibody can be used for detection of AGTR1 by ELISA at 1:62500. AGTR1 antibody can be used for detection of AGTR1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

AGTR1

Angiotensin II receptor, type 1

Homo sapiens

Kurland, L., (2008) Am. J. Hypertens. 21 (7), 836-839.

AGTR1, AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1R, AT1AR, AT1BR

ELISA, WB

395455058