UTX Antibody

• Background :

  UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

• NCBI Gene ID :

  7403

• Swiss Prot :

  O15550

• Accession Number :

  NP_066963

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UTX.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Transcription

• Purification :

  Antibody is purified by peptide affinity chromatography method.

• Positive Control :

  Cat. No. 1219 - MCF7 Cell Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store UTX antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  154 kDa

• Applications Notes :

  UTX antibody can be used for detection of UTX by ELISA at 1:312500. UTX antibody can be used for detection of UTX by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  KDM6A

• NCBI Official Name :

  Lysine (K) -specific demethylase 6A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Hong, S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444.

• Other Product Names :

  UTX, DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2

• Tested Applications :

  ELISA, WB

• Protein ID :

  189011544

• Physical Properties :

  Liquid