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UTX Antibody

CAT: 0223-25-522Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-25-522Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
NCBI Gene ID
7403
Swiss Prot
O15550
Accession Number
NP_066963
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UTX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1219 - MCF7 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store UTX antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
154 kDa
Applications Notes
UTX antibody can be used for detection of UTX by ELISA at 1:312500. UTX antibody can be used for detection of UTX by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
KDM6A
NCBI Official Name
Lysine (K) -specific demethylase 6A
NCBI Organism
Homo sapiens
Background Reference 01
Hong, S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444.
Other Product Names
UTX, DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2
Tested Applications
ELISA, WB
Protein ID
189011544
Physical Properties
Liquid

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