CHRFAM7A Antibody

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7 is located on chromosome 15 in a region associated with several neuropsychiatric disorders. CHRFAM7A is is a hybrid between CHRNA7 and FAM7A. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A) . Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

89832

Q8IUZ4

NP_683709

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRFAM7A.

Unconjugated

Primary Antibodies

Membrane, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

293T Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CHRFAM7A antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

35 kDa

CHRFAM7A antibody can be used for detection of CHRFAM7A by ELISA at 1:62500. CHRFAM7A antibody can be used for detection of CHRFAM7A by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

CHRFAM7A

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion

Homo sapiens

Martin, L.F., (2007) Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (5), 611-614.

CHRFAM7A, CHRNA7, CHRNA7-DR1, D-10, MGC120482, MGC120483

ELISA, WB

23312390