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SRY Antibody

CAT: 0223-25-229Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-25-229Size:100 µL
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Background
SRY is an intronless gene that encodes for a transcription factor, which is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
6736
Swiss Prot
Q05066
Accession Number
NP_003131
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SRY.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SRY antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
24 kDa
Applications Notes
SRY antibody can be used for detection of SRY by ELISA at 1:62500. SRY antibody can be used for detection of SRY by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SRY
NCBI Official Name
Sex determining region Y
NCBI Organism
Homo sapiens
Background Reference 01
Queralt, R., (2008) Am. J. Med. Genet. A 146A (10), 1335-1340.
Other Product Names
SRY, TDF, TDY, SRXX1, SRXY1
Tested Applications
ELISA, WB
Protein ID
4507225
Physical Properties
Liquid

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