Products for Research Use Only
RegisterLogin

NFX1 Antibody

CAT: 0223-25-227Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-25-227Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
NCBI Gene ID
4799
Swiss Prot
Q12986-2
Accession Number
NP_667344
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NFX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NFX1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
113 kDa
Applications Notes
NFX1 antibody can be used for detection of NFX1 by ELISA at 1:62500. NFX1 antibody can be used for detection of NFX1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NFX1
NCBI Official Name
Nuclear transcription factor, X-box binding 1
NCBI Organism
Homo sapiens
Background Reference 01
Katzenellenbogen, R.A., (2007) J. Virol. 81 (8), 3786-3796.
Other Product Names
NFX1, DKFZp779G2416, MGC20369, NFX2, Tex42, TEG-42
Tested Applications
ELISA, WB
Protein ID
22212925
Physical Properties
Liquid

Related Products

CatalogName
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody
15-580POMGNT2 Antibody
35-153Cytomegalovirus Antibody

Alternative Products

CatalogName
C44985-01NFX1 Antibody
JOT-AP02229-01NFX1 Polyclonal Antibody
GTR18217998-01Rabbit NFX1 Antibody
STJ191544Anti-NFX1 antibody

Popular Products