BCCIP Antibody

• Background:

  This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

• NCBI Gene ID:

  56647

• Swiss Prot:

  Q9P287

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Chemokines & Cytokines, Immunology

• Purification:

  Affinity purification

• Positive Control:

  SKOV3

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 50kDa

• Fragment:

  IgG

• Symbol:

  BCCIP

• Positive Control 2:

  HeLa

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Mouse small intestine

• NCBI Official Name:

  BRCA2 and CDKN1A interacting protein

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TOK-1, TOK1, BRCA2 and CDKN1A-interacting protein, BCCIPalpha, BCCIPbeta, BRCA2 and Cip1/p21 interacting protein, TOK-1alpha, TOK-1beta, cdk inhibitor p21 binding protein, p21- and CDK-associated protein 1, protein TOK-1

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid