DROSHA Antibody

• Background :

  This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.

• NCBI Gene ID :

  29102

• Swiss Prot :

  Q9NRR4

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DROSHA (NP_037367.3) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  K-562

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 180kDa

• Fragment :

  IgG

• Symbol :

  DROSHA

• NCBI Official Name :

  Drosha, ribonuclease type III

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  Rnasen, ribonuclease III, nuclear, 1110013A17Rik, AI874853, Etohi2, MGC115770, Rn3, ethanol induced 2, Drosha, RN3, RNASE3L, RNASEN

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid