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PHKB Antibody

CAT: 0223-23-353Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-23-353Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.
NCBI Gene ID
5257
Swiss Prot
Q93100
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 854-1093 of human PHKB (NP_000284.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 125kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
PHKB
Positive Control 2
SW620
Positive Control 3
Jurkat
Positive Control 4
BT-474
NCBI Official Name
Phosphorylase kinase regulatory subunit beta
NCBI Organism
Homo sapiens
Other Product Names
Phosphorylase b kinase regulatory subunit beta, phosphorylase kinase beta-subunit, phosphorylase kinase subunit beta, phosphorylase kinase, beta
Tested Applications
WB
Physical Properties
Liquid

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