NOTCH1 Antibody, KO Validated

• Background:

  This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

• NCBI Gene ID:

  4851

• Swiss Prot:

  P46531

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human NOTCH1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction, Stem Cell, Transcription

• Purification:

  Affinity purification

• Positive Control:

  MCF-7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 300kDa

• Fragment:

  IgG

• Symbol:

  NOTCH1

• Positive Control 2:

  293T

• Positive Control 3:

  OVCAR3

• Positive Control 4:

  Mouse thymus

• NCBI Official Name:

  Notch 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  NOTCH1, TAN1, hN1

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid