PTPRE Antibody

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.

• NCBI Gene ID:

  5791

• Swiss Prot:

  P23469

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human PTPRE (NP_006495.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HL-60

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 81kDa

• Fragment:

  IgG

• Symbol:

  PTPRE

• Positive Control 2:

  SW620

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse spleen

• Positive Control 5:

  Mouse lung

• Positive Control 6:

  Rat brain

• NCBI Official Name:

  Protein tyrosine phosphatase, receptor type, E

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PTPRE, DKFZp313F1310, HPTPE, PTPE, R-PTP-EPSILON

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid