TRAF4 Antibody

• Background:

  This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD (P) H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.

• NCBI Gene ID:

  9618

• Swiss Prot:

  Q9BUZ4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 251-470 of human TRAF4 (NP_004286.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Growth Factors, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  MCF7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 54kDa

• Fragment:

  IgG

• Symbol:

  TRAF4

• Positive Control 2:

  Mouse liver

• NCBI Official Name:

  TNF receptor-associated factor 4

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TRAF4, CART1, MLN62, RNF83

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid