TRAF2 Antibody

CAT: 0223-3663-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3663-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-κ B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
NCBI Gene ID
7186
Swiss Prot
Q12933
Accession Number
CAI15106
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Cancer
Purification
TRAF2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
TRAF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TRAF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TRAF2
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
TNF receptor-associated factor 2
NCBI Organism
Homo sapiens
Background Reference 01
Arch RH, Gedrich RW, and Thompson CB. Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adaptor proteins that regulate life and death. Genes Dev.1998; 12:2821-30.
Background Reference 02
Van Kooten C and Bancherau J. CD40-CD40 ligand. J. Leukoc. Biol.2000; 67:2-17.
Background Reference 03
Grech AP, Amesbury M, Chan T, et al. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity2004; 21:629-42.
Background Reference 04
Davies CC, Mak TW, Young LS, et al. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol. Cell. Biol.2005; 25:9806-19.
Other Product Names
TRAF2 Antibody: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2
Tested Applications
ELISA, WB, IHC-P, IF, IP
Protein ID
55959980
Physical Properties
Liquid

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