TRAF2 Antibody

• Background:

  TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-κ B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

• NCBI Gene ID:

  7186

• Swiss Prot:

  Q12933

• Accession Number:

  CAI15106

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Cancer

• Purification:

  TRAF2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1404 - Mouse Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TRAF2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TRAF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  Observed: 53 kDa

• Fragment:

  IgG

• Symbol:

  TRAF2

• NCBI Official Name:

  TNF receptor-associated factor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Arch RH, Gedrich RW, and Thompson CB. Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adaptor proteins that regulate life and death. Genes Dev.1998; 12:2821-30.

• Background Reference 02:

  Van Kooten C and Bancherau J. CD40-CD40 ligand. J. Leukoc. Biol.2000; 67:2-17.

• Background Reference 03:

  Grech AP, Amesbury M, Chan T, et al. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity2004; 21:629-42.

• Background Reference 04:

  Davies CC, Mak TW, Young LS, et al. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol. Cell. Biol.2005; 25:9806-19.

• Other Product Names:

  TRAF2 Antibody: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2

• Tested Applications:

  ELISA, WB, IHC-P, IP

• Protein ID:

  55959980

• Physical Properties:

  Liquid