PSMD12 Antibody

• Background :

  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  5718

• Swiss Prot :

  O00232

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 197-456 of human PSMD12 (NP_002807.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  Affinity purification

• Positive Control :

  MCF7

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 53kDa

• Fragment :

  IgG

• Symbol :

  PSMD12

• Positive Control 2 :

  BT-474

• Positive Control 3 :

  HT-29

• Positive Control 4 :

  Mouse heart

• Positive Control 5 :

  Rat heart

• Positive Control 6 :

  Rat lung

• NCBI Official Name :

  26S proteasome non-ATPase regulatory subunit 12

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit RPN5, 26S proteasome regulatory subunit p55, PSMD12

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid