PSMD10 Antibody

CAT: 0223-57-836Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-836Size:400 µL
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Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
NCBI Gene ID
5716
Swiss Prot
O75832
Accession Number
O75832
Host
Rabbit
Reactivity
Human
Immunogen
This PSMD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-213 amino acids from the C-terminal region of human PSMD10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PSMD10
NCBI Official Name
26S proteasome non-ATPase regulatory subunit 10
NCBI Organism
Homo sapiens
Background Reference 01
Meng, Y., et al. Cancer Lett. 297 (1) :9-17 (2010)
Background Reference 02
Man, J.H., et al. J. Clin. Invest. 120 (8) :2829-2841 (2010)
Background Reference 03
Piton, A., et al. Mol. Psychiatry (2010) In press :
Background Reference 04
Serquera, D., et al. Biophys. J. 98 (7) :1294-1301 (2010)
Other Product Names
26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit p28, Gankyrin, p28 (GANK), PSMD10
Tested Applications
WB
Physical Properties
Liquid

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