MLPH Antibody

• Background :

  This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  79083

• Swiss Prot :

  Q9BV36

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 301-600 of human MLPH (NP_077006.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  Mouse stomach

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 75kDa

• Fragment :

  IgG

• Symbol :

  MLPH

• NCBI Official Name :

  Melanophilin

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a, MLPH, SLAC2A

• Tested Applications :

  WB, IHC, IF

• Physical Properties :

  Liquid