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GALE Antibody

CAT: 0223-22-339Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-22-339Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form) . Multiple alternatively spliced transcripts encoding the same protein have been identified.
NCBI Gene ID
2582
Swiss Prot
Q14376
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
SW480
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 38kDa
Fragment
IgG
Symbol
GALE
Positive Control 2
SKOV3
Positive Control 3
HepG2
Positive Control 4
U-251MG
Positive Control 5
HeLa
Positive Control 6
Mouse liver
NCBI Official Name
UDP-galactose-4-epimerase
NCBI Organism
Homo sapiens
Other Product Names
GALE, SDR1E1
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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