CD207 Antibody

• Background:

  The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.

• NCBI Gene ID:

  50489

• Swiss Prot:

  Q9UJ71

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 69-328 of human CD207 (NP_056532.4) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HT-29

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 37kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  CD207

• Positive Control 2:

  HepG2

• Positive Control 3:

  Mouse liver

• NCBI Official Name:

  CD207 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CLEC4K, C-type lectin domain family 4 member K, C-type lectin domain family 4, member K, CD207 antigen, langerin, CD207 molecule, langerin, Langerhans cell specific c-type lectin

• Tested Applications:

  WB

• Physical Properties:

  Liquid