CD27 Antibody

• Background:

  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

• NCBI Gene ID:

  939

• Swiss Prot:

  P26842

• Accession Number:

  P26842

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human CD27.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD27

• NCBI Official Name:

  CD27 antigen

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jiang, J., et al. J. Clin. Immunol. 30 (4) :566-573 (2010)

• Background Reference 02:

  Arimoto-Miyamoto, K., et al. Immunology 130 (1) :137-149 (2010)

• Background Reference 03:

  Mizuochi, T., et al. J. Interferon Cytokine Res. 30 (4) :243-252 (2010)

• Background Reference 04:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Other Product Names:

  CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7

• Tested Applications:

  WB, Flow

• Protein ID:

  269849546

• Physical Properties:

  Liquid