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CD27 Antibody

CAT: 0223-57-238Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-238Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
NCBI Gene ID
939
Swiss Prot
P26842
Accession Number
P26842
Host
Rabbit
Reactivity
Human
Immunogen
This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human CD27.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
CD27
NCBI Official Name
CD27 antigen
NCBI Organism
Homo sapiens
Background Reference 01
Jiang, J., et al. J. Clin. Immunol. 30 (4) :566-573 (2010)
Background Reference 02
Arimoto-Miyamoto, K., et al. Immunology 130 (1) :137-149 (2010)
Background Reference 03
Mizuochi, T., et al. J. Interferon Cytokine Res. 30 (4) :243-252 (2010)
Background Reference 04
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Other Product Names
CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7
Tested Applications
WB, Flow
Protein ID
269849546
Physical Properties
Liquid

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