C4BPB Antibody

• Background :

  This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.

• NCBI Gene ID :

  725

• Swiss Prot :

  P20851

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human C4BPB (NP_001017364.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology, Innate Immunity

• Purification :

  Affinity purification

• Positive Control :

  HT-29

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 54kDa

• Fragment :

  IgG

• Symbol :

  C4BPB

• Positive Control 2 :

  HepG2

• Positive Control 3 :

  Mouse testis

• Positive Control 4 :

  Rat testis

• NCBI Official Name :

  Complement component 4 binding protein, beta

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  C4BPB, C4BP

• Tested Applications :

  WB, IHC, IF

• Physical Properties :

  Liquid