CISH Antibody

• Background:

  The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1154

• Swiss Prot:

  Q9NSE2

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH (NP_659508.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  Mouse liver

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 37kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  CISH

• NCBI Official Name:

  Cytokine inducible SH2 containing protein

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  BACTS2, CIS, CIS-1, G18, SOCS, cytokine-inducible SH2-containing protein, cytokine-inducible inhibitor of signaling type 1B, suppressor of cytokine signaling

• Tested Applications:

  WB

• Physical Properties:

  Liquid