ALS2 Antibody

• Background :

  The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  57679

• Swiss Prot :

  Q96Q42

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ALS2 (NP_065970.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Neuroscience

• Purification :

  Affinity purification

• Positive Control :

  Mouse testis

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 174kDa

• Fragment :

  IgG

• Symbol :

  ALS2

• Positive Control 2 :

  Mouse thymus

• NCBI Official Name :

  Amyotrophic lateral sclerosis 2 (juvenile)

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  ALS2, amyotrophic lateral sclerosis 2 (juvenile), ALSJ, PLSJ, IAHSP, KIAA1563, ALS2CR6

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid