DYNC2LI1 Antibody

• Background:

  This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15) . Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• NCBI Gene ID:

  51626

• Swiss Prot:

  Q8TCX1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human DYNC2LI1 (NP_001180393.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-251MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 38kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  DYNC2LI1

• Positive Control 2:

  Jurkat

• Positive Control 3:

  293T

• Positive Control 4:

  A-549

• Positive Control 5:

  Mouse testis

• Positive Control 6:

  Mouse eye

• NCBI Official Name:

  Dynein cytoplasmic 2 light intermediate chain 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CGI-6D2LIC, LIC3, cytoplasmic dynein 2 light intermediate chain 1

• Tested Applications:

  WB

• Physical Properties:

  Liquid