EPOR Antibody

• Background:

  This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  2057

• Swiss Prot:

  P19235

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 274-508 of human EPOR (NP_000112.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Immunology, Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  K-562

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 55kDa

• Fragment:

  IgG

• Symbol:

  EPOR

• Positive Control 2:

  Mouse kidney

• Positive Control 3:

  Rat liver

• NCBI Official Name:

  Erythropoietin receptor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  EPOR, MGC138358, EPO-R

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid