DMAP1 Antibody

• Background:

  This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

• NCBI Gene ID:

  55929

• Swiss Prot:

  Q9NPF5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human DMAP1 (NP_061973.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  SH-SY5Y

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 60kDa

• Fragment:

  IgG

• Symbol:

  DMAP1

• Positive Control 2:

  SW480

• Positive Control 3:

  A375

• Positive Control 4:

  HeLa

• Positive Control 5:

  Jurkat

• Positive Control 6:

  NIH/3T3

• NCBI Official Name:

  DNA methyltransferase 1 associated protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DMAP1, EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid