VDR Antibody

• Background:

  This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.

• NCBI Gene ID:

  7421

• Swiss Prot:

  P11473

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction, Transcription

• Purification:

  Affinity purification

• Positive Control:

  Mouse kidney

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 43kDa

• Fragment:

  IgG

• Symbol:

  VDR

• NCBI Official Name:

  Vitamin D (1,25- dihydroxyvitamin D3) receptor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  VDR, vitamin D (1, 25- dihydroxyvitamin D3) receptor, HGNC:12679, NR1I1, 25-dihydroxyvitamin D3) receptor

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid