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VDR Antibody

CAT: 0223-18-567Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-18-567Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
NCBI Gene ID
7421
Swiss Prot
P11473
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
Mouse kidney
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 43kDa
Fragment
IgG
Symbol
VDR
NCBI Official Name
Vitamin D (1,25- dihydroxyvitamin D3) receptor
NCBI Organism
Homo sapiens
Other Product Names
VDR, vitamin D (1, 25- dihydroxyvitamin D3) receptor, HGNC:12679, NR1I1, 25-dihydroxyvitamin D3) receptor
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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